Anti-Human DEDD2

PN:D324

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human DEDD2 recognizes an epitope near the N-terminus of mouse, rat and human DEDD2. This polyclonal antibody was purified using affinity chromatography.

Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain.¹ A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD.² More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD.^2,3 Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis.³ At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

1. Tibbetts, MD. et al. (2003) Nat. Immunol. 4:404-9.
2. Roth, W. et al. (2002) J. Biol. Chem. 277:7501-8.
3. Alcivar, A. et al. (2003) Oncogene 22:291-7.