Anti-Human DR5 (CT)

Pricing & Details

Product No.D251
Protein
DR5
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Apo2, TRAIL-R2, TRICK2, KILLER
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D251-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D251-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:D279
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DR5 recognizes an epitope near the C-terminus of mouse and human DR5. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently.1-4 Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.

Antigen Details

Protein
PubMed

References & Citations

1. Pan, G. et al. (1997) Science 277:815-8
2. Sheridan, JP. et al. (1997) Science 277:818-21
3. Walczak, H. et al. (1997) EMBO J 16:5386-97
4. MacFarlane, M. et al. (1997) J Biol Chem 272:25417-20
IHC
General Western Blot Protocol
Prod No.
Description
D279
D251
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Leinco Technologies uses cookies to improve your experience and our website service. By continuing to browse our website, you accept our cookie policy. Ok