Anti-Human DR6 (NT)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen Purified Recombinant Human DR6 (>98%) Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2829908 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human DR6 recognizes an epitope near the N-terminus of Human DR6. This polyclonal antibody was purified using affinity chromatography. Background Death receptor-6 (DR6), a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues and regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4(+) T cell proliferation and T helper 2 differentiation in vitro.1 DR6 contains an extracellular region and an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals.2 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. PubMed References & Citations1. Dixit, VM. et al. (1998) FEBS Lett. 431(3):351-6. Technical ProtocolsCertificate of Analysis |
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