Anti-Human DR6 (NT)

Pricing & Details

Product No.D254
Protein
DR6
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Death Receptor 6, TNFRSF21
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D254-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D254-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human DR6 (>98%)
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DR6 recognizes an epitope near the N-terminus of Human DR6. This polyclonal antibody was purified using affinity chromatography.
Background
Death receptor-6 (DR6), a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues and regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4(+) T cell proliferation and T helper 2 differentiation in vitro.1 DR6 contains an extracellular region and an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals.2 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK.

Antigen Details

Protein
PubMed

References & Citations

1. Dixit, VM. et al. (1998) FEBS Lett. 431(3):351-6.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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