Anti-Human FLASH (CT)

Pricing & Details

Product No.F138
Protein
FLASH
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
FLICE-Associated Huge Protein, FLICE Associated Huge Protein
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
F138-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
F138-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:F145
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human FLASH recognizes and epitope near the C-terminus of Human FLASH. This polyclonal antibody was purified using affinity chromatography.
Background
A novel mammalian CED-4 homologous was recently identified and cloned in mouse1 and human2 and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.1 There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.1,2 FLASH is widely expressed.

Antigen Details

Protein
PubMed

References & Citations

1. Imai, Y. et al. (1999) Nature 398:777-85
2. Koonin, EV. et al. (1999) Nature 401:662-3
3. Medema JP. (1999) Nature. 398(6730):756-7.
IHC
General Western Blot Protocol
Prod No.
Description
F138
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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