Anti-Human I-Kappa-B Kinase Epsilon (CT) (IKKε)

Anti-Human I-Kappa-B Kinase Epsilon (CT) (IKKε)

Product No.: I-303

[product_table name="All Top" skus="I-303"]

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Target
I-Kappa-B Kinase Epsilon
Product Type
Polyclonal Antibody
Alternate Names
IKKi (CT)
Applications
IHC FFPE
,
WB

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Data

I-303 Western Blot
I-303 IHC Human Pancreas
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:I-327
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human I-Kappa-B Kinase Epsilon (IKKε) recognizes an epitope near the C-terminus of Human IKKε. This polyclonal antibody was purified using affinity chromatography.
Background
Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. IkB is phosphorylated by IkB kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ. A novel molecule in the IKK complex was recently identified and designated IKKε/IKK-i.1,2 IKKe is required for the activation of NF-κB by PMA and T cell receptors but not by TNFα and IL-1.1 IKKε/IKK-i message is supexpressed in a variety of tissues and is inducible by TNFα, IL-1, and LPS.2

Antigen Details

References & Citations

1. Peters, RT. et al. (2000) Mol. Cell 5(3):513
2. Shimada, T. et al. (1999) Int. Immunol. 11(8):1357
IHC FFPE
General Western Blot Protocol

Certificate of Analysis

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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.