Anti-Human IL-1 Receptor Associated Kinase 2 (CT-1) (IRAK-2)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human IL-1 Receptor Associated Kinase 2 (CT-1) (IRAK-2)

Pricing & Details

Product No.I-309
Protein
IRAK-2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Interleukin-1 Receptor Associated Kinase 2
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-309-220ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
I-309-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:I-324
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human IL-1 Receptor Associated Kinase 2 (IRAK2) recognizes an epitope near the C-terminus of Human IRAK2. This polyclonal antibody was purified using affinity chromatography.
Background
The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κB , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2.2 Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κB activation.3,4 Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.

Antigen Details

Protein
PubMed

References & Citations

1. Cao, Z. et al. (1996) Science 271:1128
2. Muzio, M. et al. (1997) Science 278:1612
3. Zhang, FX. et al. (1999) J. Biol. Chem. 274:7611
4. Yang, RB. et al. (1999) J. Immunol. 163:639
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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