Anti-Human IL-1ra

Purified Recombinant Human IL-1ra (Accession # P18510)

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

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Neutralization: This antibody is useful for neutralization of Human IL-1ra bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-1ra (at 50 ng/ml) is 10-20 µg/ml.

Mouse Anti-Human Interleukin 1 Receptor Antagonist (IL-1ra) (Clone 10309) recognizes an epitope on Human IL-1ra. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.