Anti-Human IL-5 (Clone14611)

Pricing & Details

Product No.I-632
Clone
14611
Protein
IL-5
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Interleukin-5, EDF, BCDFII, TRF
Isotype
Mouse
IgG1
Applications
N
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-632-25 µg
25 µg
$150.00
In stock
Max:
Min: 1
Step: 1
I-632-100 µg
100 µg
$420.00
In stock
Max:
Min: 1
Step: 1
I-632-500 µg
500 µg
$935.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human IL-5 (Accession # P05113)
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Other Applications Reported In Literature ?
Neutralization: This antibody is useful for neutralization of Human IL-5 bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human IL-5 (at 1.25 ng/ml) is 0.01 - 0.03 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 14611 recognizes an epitope on human IL-5. In direct ELISA, this antibody shows approximately 3% cross-reactivity with rmIL-5.
Background
IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.

Antigen Details

Protein
PubMed

References & Citations

1. Capron, M. et al. (1994) J Exp Med 179: 703
2. Graber, P. et al. (1993) Nature 363: 172
3. Inokuma, S. et al. (2005) Int Arch Allergy Immunol 1: 55

Formats Available

Prod No.
Description
I-632
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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