Anti-Human ILP-2 (NT)

Pricing & Details

Product No.I-362
Protein
ILP-2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Inhibitor of Apoptosis Like Protein-2
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-362-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
I-362-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:I-363
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human ILP-2 recognizes an epitope near the N-terminus of mouse, rat and human ILP-2. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2.1 ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues.1 ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Antigen Details

Protein
PubMed

References & Citations

1. Richter, BW. et al. (2001) Mol Cell Biol. 21(13):4292-301.
IHC
General Western Blot Protocol
Prod No.
Description
I-362
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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