Anti-Human Ipaf

PN:I-497

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Ipaf recognizes an epitope near the C-terminus of human Ipaf. This polyclonal antibody was purified using affinity chromatography.

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-κB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family.¹ Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner.^2,3 Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.

1. Li, P. et al. (1997) Cell. 91(4):479-89.
2. Poyet, JL. et al. (2001) J Biol Chem. 276 (30):28309-13.
3. Geddes, BJ. et al. (2001) Biochem Biophys Res Commun. 284(1):77-82.