Anti-Human Ipaf
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:I-497 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830708 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human Ipaf recognizes an epitope near the C-terminus of human Ipaf. This polyclonal antibody was purified using affinity chromatography. Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-κB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family.1 Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner.2,3 Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1. PubMed References & Citations1. Li, P. et al. (1997) Cell. 91(4):479-89. 2. Poyet, JL. et al. (2001) J Biol Chem. 276 (30):28309-13. 3. Geddes, BJ. et al. (2001) Biochem Biophys Res Commun. 284(1):77-82. Technical ProtocolsCertificate of Analysis |
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