Pricing & Details

Product No.I-490
Protein
Ipaf
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
ICE Protease Activating Factor, CARD12, CLANA
Applications
IHC FF
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-490-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
I-490-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:I-497
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Ipaf recognizes an epitope near the C-terminus of human Ipaf. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-κB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family.1 Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner.2,3 Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.

Antigen Details

Protein
PubMed

References & Citations

1. Li, P. et al. (1997) Cell. 91(4):479-89.
2. Poyet, JL. et al. (2001) J Biol Chem. 276 (30):28309-13.
3. Geddes, BJ. et al. (2001) Biochem Biophys Res Commun. 284(1):77-82.
IHC
IHC
General Western Blot Protocol
Prod No.
Description
I-497
I-490
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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