Anti-Human IRAK-4
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:I-483 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830698 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human IRAK-4 recognizes an epitope near the C-terminus of Human IRAK-4. This polyclonal antibody was purified using affinity chromatography. Background Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-κB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4.4 Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity. PubMed References & Citations1. Cao, Z. et al. (1996) Science 271:1128 2. Muzio, M. et al. (1997) Science 278:1612 3. Wesche, H. et al. (1999) J. Biol. Chem. 274(27):19403 4. Li, S. et al. (2002) Proc. Natl. Acad. Sci. USA 99(8):5567 Technical ProtocolsCertificate of Analysis |
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