Anti-Human Lano (CT)

Pricing & Details

Product No.L172
Protein
Lano
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
LRRC1
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
L172-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
L172-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:L177
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Lano recognizes an epitope near the C-terminus of Human Lano. This polyclonal antibody was purified using affinity chromatography.
Background
Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble.1 The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells.2 Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions.1,3 It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.4

Antigen Details

Protein
PubMed

References & Citations

1. Saito, H. et al. (2001) J. Biol. Chem. 276:32051
2. Legouis, R. et al. (2003) EMBO Rep. 4:1096
3. Funke, L. et al. (2005) Annu. Rev. Biochem. 74:219
4. Bilder, D. et al. (2000) Nature 403:676
IHC
General Western Blot Protocol
Prod No.
Description
L177
L172
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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