Anti-Human NALP2

PN:N171

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human NALP2 recognizes Human, Mouse and Rat NALP2. This polyclonal antibody was purified using affinity chromatography.

NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.¹ Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD).² This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1Β-processing activity and is thought to function as a modulator of NF-κB and procaspase-1 activation in macrophages.^2,3 It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs).⁴ At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.

1. Tschopp, J. et al. (2003) Nat. Rev. Mol. Cell Biol. 4:95
2. Bruey, JM. et al. (2004) J. Biol. Chem. 279:51897
3. Agostini, L. et al. (2004) Immunity 20:319
4. Martinon, F. et al. (2005) TRENDS Imm. 26:447