Anti-Human Nerve Growth Factor Receptor (NGFR) Antibody (34064)
Anti-Human Nerve Growth Factor Receptor (NGFR) Antibody (34064)
Product No.: 34064
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Clone G637.1 Target Nerve Growth Factor Receptor (NGFR) Formats AvailableView All Product Type Monoclonal Alternate Names Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD antigen CD271 Isotype Mouse IgG1 Applications IHC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Recombinant human NGFR. Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide. State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling Store at 2-8°C. Do not freeze. Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to Nerve Growth Factor Receptor (NGFR) Background Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed on Schwann cells and neurons as well as a number of other non-neuronal cell types, and it functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. Nerve Growth Factor Receptor is also expressed on melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurobromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives. Function Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). {UniProtKB:Q9Z0W1, PubMed:14966521, PubMed:23785138, PubMed:24908487, PubMed:26646181, PubMed:3022937}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & Citations |
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