Anti-Human NF-κB Activating Kinase (CT) (NAK)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human NF-κB Activating Kinase (CT) (NAK)

Pricing & Details

Product No.N130
Protein
NF-κB Activating Kinase
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
TBK1
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
N130-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
N130-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:N151
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human NF-κB Activating Kinase (NAK) recognizes an epitope near the C-terminus of Human and Mouse NAK. This polyclonal antibody was purified using affinity chromatography.
Background
Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. Phosphorylation of I-κB by IκB kinase (IKK) complex leads to degradation of I-κB and activation of NF-κB. The IKK complex contains IKKα, IKKβ, and IKKγ. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-κB-activating kinase), and T2K.1-3 NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-κB activation in response to growth factors.2 NAK/TBK1 functions upstream of NIK and the IKK complex.1,2 NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.3

Antigen Details

References & Citations

1. Pomerantz, JL. et al. (1999) EMBO J. 18(23):6694
2. Tojima, Y. et al. (2000) Nature 404(6779):778
3. Bonnard, M. et al. (2000) EMBO J. 19(18):4976
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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