Anti-Human Nudel

Pricing & Details

Product No.N150
Protein
Nudel
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FF
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
N150-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
N150-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:N150
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Nudel recognizes Human and Mouse Nudel. This polyclonal antibody was purified using affinity chromatography.
Background
Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration.1,2 It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology.1,3 It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions.4 Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus.3

Antigen Details

Protein
PubMed

References & Citations

1. Niethammer, H. et al. (2000) Neuron 28:697
2. Liu, Z. et al. (2000) Nat. Cell Biol. 2:776
3. Gupta, A. et al. (2003) Neurosignals 12:173
4. Liang, Y. et al. (2004) J. Cell Biol. 164:557
IHC
IHC
General Western Blot Protocol
Prod No.
Description
N152
N150
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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