Anti-Human p34^cdc2 Serine/Threonine Kinase Purified

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This purified antibody is stable when stored at 2-8°C. Do not freeze.

Next Day 2-8°C

Mouse Anti-Human p34^cdc2 Serine/Threonine Kinase (p34^cdc2 Serine/Threonine Kinase) (Clone 17) recognizes an epitope on Human p34^cdc2 Serine/Threonine Kinase near the C-terminus in human, mouse, or xenopus cells. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

p34^cdc2 is thought to be activated by cyclin through dephosphorylation at tyrosine residues. Activated p34^cdc2 kinase is involved in a number of mitotic events such as nuclear envelope breakdown and chromosome condensation through phosphorylation of serine/threonine residues of substrates such as nuclear lamins, histones, pp60c-src, nucleolin and RNA polymerase II. It is then inactivated by a tyrosine kinase. Anti-p34^cdc2 can be used in western blotting, immunoprecipitation and immunohistochemistry. The antibody precipitates an active kinase.

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