Anti-Human p34cdc2 Serine/Threonine Kinase – DyLight® 488

Anti-Human p34cdc2 Serine/Threonine Kinase – DyLight® 488

Product No.: P312

[product_table name="All Top" skus="P312"]

- -
- -
Clone
17
Target
p34cdc2 Serine/Threonine Kinase
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
IgG2a
Applications
FC

- -
- -
Select Product Size
- -
- -

Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human p34cdc2 Serine/Threonine Kinase (>98%)
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Blue Laser (493 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human p34cdc2 Serine/Threonine Kinase (Clone 17) recognizes an epitope on Human p34cdc2 Serine/Threonine Kinase. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
p34cdc2 is thought to be activated by cyclin through dephosphorylation at tyrosine residues. Activated p34cdc2 kinase is involved in a number of mitotic events such as nuclear envelope breakdown and chromosome condensation through phosphorylation of serine/threonine residues of substrates such as nuclear lamins, histones, pp60c-src, nucleolin and RNA polymerase II. It is then inactivated by a tyrosine kinase. Anti-p34cdc2 can be used in western blotting, immunoprecipitation and immunohistochemistry. The antibody precipitates an active kinase.

Antigen Details

NCBI Gene Bank ID
Research Area
Apoptosis
.
Cell Biology

References & Citations

1. Moreno, S. et al. (1990) Cell 61:549
2. Ward, GE. et al. (1990) Cell 61:561
3. Langan, TA. et al. (1989) Mol. Cell. Biol. 9:3860
Flow Cytometry

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.