Anti-Human p53 Upregulated Modulator of Apoptosis (NT) (PUMA)

Pricing & Details

Product No.P157
Protein
p53 Upregulated Modulator of Apoptosis
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
bbc3
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P157-0.1 mg
0.1 mg
$315.00
In stock
Max:
Min: 1
Step: 1
P157-0.5 mg
0.5 mg
$990.00
In stock
Max:
Min: 1
Step: 1
P157-1 mg
1 mg
$1,880.00
In stock
Max:
Min: 1
Step: 1

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:P158
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human p53 Upregulated Modulator of Apoptosis (PUMA) recognizes an epitope near the N-terminus of Human PUMA. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse.1-3 PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β1 PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Antigen Details

References & Citations

1. Nakano, K. et al. (2001) Mol Cell. 7(3):683
2. Han, J. et al. (2001) Proc. Natl. Acad. Sci. USA 98(20):11318
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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