Anti-Human p53DINP1 (SIP)

Anti-Human p53DINP1 (SIP)

Product No.: P159

[product_table name="All Top" skus="P159"]

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Target
P53DINP1
Product Type
Polyclonal Antibody
Alternate Names
p53 Dependent Damage Inducible Nuclear Protein, SIP
Applications
IHC FFPE
,
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:P160
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human p53 Dependent Damage Inducible Nuclear Protein (P53DINP1) recognizes an epitope near the N-terminus of human, mouse and rat P53DINP1. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse (1,2). A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks (1). p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-α and p53DINP1-β or SIP27 and SIP18 (1,2). p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress (2).

Antigen Details

PubMed

References & Citations

1. Okamura, S. et al. (2001) Mol Cell. 8(1):85-94.
2. Tomasini, R. et al. (2001) J Biol Chem. 276(47):44185-92.
IHC FFPE
General Western Blot Protocol
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Prod No.
Description
P159
Products are for research use only. Not for use in diagnostic or therapeutic procedures.