Anti-Human p53DINP1 (SIP)

Pricing & Details

Product No.P159
Protein
P53DINP1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
p53 Dependent Damage Inducible Nuclear Protein, SIP
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P159-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
P159-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:P160
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human p53 Dependent Damage Inducible Nuclear Protein (P53DINP1) recognizes an epitope near the N-terminus of human, mouse and rat P53DINP1. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse (1,2). A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks (1). p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-α and p53DINP1-β or SIP27 and SIP18 (1,2). p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress (2).

Antigen Details

Protein
PubMed

References & Citations

1. Okamura, S. et al. (2001) Mol Cell. 8(1):85-94.
2. Tomasini, R. et al. (2001) J Biol Chem. 276(47):44185-92.
IHC
General Western Blot Protocol
Prod No.
Description
P159
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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