Anti-Human p53R2 (NT)

Pricing & Details

Product No.P149
Protein
p53R2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
p53-inducible Ribonucleotide Reductase Small Subunit 2-like Protein
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P149-0.1 mg
0.1 mg
$345.00
In stock
Max:
Min: 1
Step: 1

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:P151
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human p53R2 recognizes an epitope near the amino terminus of human, mouse and rat p53R2. This polyclonal antibody was purified using affinity chromatography.
Background
The p53 tumor-suppresspr gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 , Chk2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase (1,7). p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression (8). p53R2 is an important target of p53 for tumour suppression.

Antigen Details

Protein
PubMed

References & Citations

1. Tanaka, H. et al. (2000) Nature. 404:42-9.
2. Matsuoka, S. et al. (1998) Science. 282:1893-7.
3. Oda, E. et al. (2000) Science. 288(5468):1053-8.
4. Oda, K. et al. (2000) Cell 102(6):849-62.
IHC
General Western Blot Protocol
Prod No.
Description
P151
P149
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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