Anti-Human PERP

Pricing & Details

Product No.P153
Protein
PERP
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
TP53 Apoptosis Effector, PIGPC1, THW
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
P153-0.1 mg
0.1 mg
$345.00
In stock
Max:
Min: 1
Step: 1

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:P154
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human PERP recognizes an epitope near the carboxy terminus of Human PERP. This polyclonal antibody was purified using affinity chromatography.
Background
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6), MTBP (7) and PERP (8), were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein (8-10). p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis (8). The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family (8).

Antigen Details

Protein
PubMed

References & Citations

1. Matsuoka, S. et al. (1998) Science. 282:1893-7.
2. Tanaka, H. et al. (2000) Nature. 404:42-9.
3. Oda, E. et al. (2000) Science. 288(5468):1053-8.
4. Oda, K. et al. (2000) Cell. 102(6):849-62.
General Western Blot Protocol
Prod No.
Description
P154
P153
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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