This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Mouse Anti-Human Phosphodiesterase V (Phosphodiesterase V) (Clone 29.29) recognizes an epitope on Human Phosphodiesterase V. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Phosphodiesterases (PDEs) are a superfamily of enzymes that degrade the intracellular second messengers cyclic AMP and cyclic GMP. These enzymes are essential regulators of cyclic nucleotide signaling with diverse physiological functions. PDEs are drug targets for the treatment of disease states including heart failure, depression, asthma, inflammation and erectile dysfunction. Of the 12 PDE gene families, cGMP specific PDE5 carries out the principal cGMP hydrolyzing activity.1,2
References & Citations
1. Piazza, G. et al. (2001) Cancer Research 61:3961-3968
2. Sung, BJ. et al. (2003) Nature 425:98-102
Products are for research use only. Not for use in diagnostic or therapeutic procedures.