Anti-Human Precerebellin (CT)

Anti-Human Precerebellin (CT)

Product No.: P196

[product_table name="All Top" skus="P196"]

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Target
Precerebellin
Product Type
Polyclonal Antibody
Alternate Names
Cerebellin precursor, Cbln1
Applications
IHC FFPE
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Precerebellin recognizes an epitope near the C-terminus of Human, Mouse and Rat Precerebellin. This polyclonal antibody was purified using affinity chromatography.
Background
Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q.1 Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway;2 and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.3 The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus.4 Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.

Antigen Details

References & Citations

1. Urade, Y. et al. (1991) Proc. Natl. Acad. Sci. USA 88:1069
2. Mazzocchi, G. et al. (1999) J. Clin. Endocrinol. Metab. 84:632
3. Albertin, G. et al. (2000) Neuropeptides 34:7
4. Shamji, AF. et al. (1985) Proc. Natl. Acad. Sci. USA 82:7145
IHC FFPE
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.