Anti-Human RP105 (Intermediate Domain)

Anti-Human RP105 (Intermediate Domain)

Product No.: R1246

[product_table name="All Top" skus="R1246"]

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Target
RP105
Product Type
Polyclonal Antibody
Alternate Names
Radioprotective 105, Lymphocyte Antigen 64, CD180 Antigen Precursor
Applications
IHC FFPE
,
WB

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Select Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:R1249
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human RP105 recognizes an epitope near the center of human and mouse RP105. This polyclonal antibody was purified using affinity chromatography.
Background
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins. One such protein is RP105, a recently identified homolog to TLR4 that, with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway (3). It has also been suggested that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes (4). Despite its predicted molecular weight, RP105 often migrates at 95 – 105 kDa.

Antigen Details

PubMed

References & Citations

1. Akira, S. et al. (2003) Annu. Rev. Immunol. 21:335-76.
2. Janeway Jr., CA. and Medzhitov, R. (2002) Annu. Rev. Immunol. 20:197-216.
3. Divanovic, S. et al. (2005) J Endotoxin Res. 11(6):363-8.
4. Nagai, Y. et al. (2005) J Immunol. 174(11):7043-9.
IHC FFPE
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.