Anti-Human SARM (CT)

Pricing & Details

Product No.S555
Protein
SARM
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Sterile Alpha and TIR Motif Containing 1
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
S555-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
S555-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:S558
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human SARM recognizes an epitope near the C-terminus of human and mouse SARM. This polyclonal antibody was purified using affinity chromatography.
Background
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kB, and ultimately the expression of proteins involved in host defense (4,5). While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule (4,5).

Antigen Details

Protein
PubMed

References & Citations

1. Fenton, MJ. et al. (2003) Mol. Interv. 3:466-77.
2. Akira, S. et al. (2003) Annu. Rev. Immunol. 21:335-76.
3. Janeway Jr., CA. and Medzhitov, R. (2002) Annu. Rev. Immunol. 20:197-216.
4. Bowie, AG. et al. (2003) Trends in Imm. 24:286-9.
General Western Blot Protocol
Prod No.
Description
S558
S555
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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