Anti-Human Slug (Intermediate Domain 1)

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Pricing & Details

Product No.S521
Protein
Slug
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Neural Crest Transcription Factor Slug, Snail Homolog 2
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
S521-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
S521-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:S530
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Slug recognizes an epitope in the intermediate domain of Human and Mouse Slug. This polyclonal antibody was purified using affinity chromatography.
Background
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-β. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.

Antigen Details

Protein
PubMed

References & Citations

1. Neito, MA. et al. (1994) Science 264:835
2. Martinez-Estrada, OM. et al. (2006) Biochim J. 394:449
3. Shioiri, M. et al. (2006) Br. J. Cancer 94:1816
4. Wu, WS. et al. (2005) Cell 123:641
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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