Anti-Human T Cell Cytokine Receptor (NT) (TCCR)

Anti-Human T Cell Cytokine Receptor (NT) (TCCR)

Product No.: T208

[product_table name="All Top" skus="T208"]

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Target
T Cell Cytokine Receptor
Product Type
Polyclonal Antibody
Alternate Names
WSX-1
Applications
IHC FFPE
,
WB

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:T327
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human T Cell Cytokine Receptor (TCCR) recognizes an epitope near the N-terminus of Human TCCR. This polyclonal antibody was purified using affinity chromatography.
Background
Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-γ and lymphotoxin-β that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned.1,2 It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1.1,2 TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-γ and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph nodes and peripheral blood leukocytes.

Antigen Details

References & Citations

1. Chen, Q. et al. (2000) Nature 407(6806):916
2. Sprecher, CA. et al. (1998) Biophys. Res. Commun. 246(1):82
IHC FFPE
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.