This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human TAB1 recognizes human and mouse TAB1. This polyclonal antibody was purified using affinity chromatography.
TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 (1), which is known to mediate various intracellular signaling pathways, such as those induced by TGF-β and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals (4,5). It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-β, demonstrating how this protein can function as a mediator between TGF-β receptors and TAK1 (6).
References & Citations
1. Shirakabe, K. et al. (1996) Science 272:1179-82.
2. Takeshige, K. et al. (2000) FEBS Lett. 467:160-4.
3. Akira, S. and Takeda, K. (2004) Nat. Rev.Immunol. 4:499-511.
4. Qian, Y. et al. (2002) Mol. Cell Biol.22:7158-67.
5. Cohen, P. et al. (2004) Biochem J. 378:27-34.
6. Ninomiya-Tsuji, J. et al. (2003) Biochem. Biophys. Res. Commun. 307:3327.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.