Anti-Human TACE (CT)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:T204 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831851 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human TNF-α Converting Enzyme (TACE) recognizes an epitope near the C-terminus of Human, Mouse and Rat TACE. This polyclonal antibody was purified using affinity chromatography. Background TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.1 TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.2 TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)3 and a principal target for the treatment of TNF-dependent pathologies.4 Antigen DetailsPubMed References & Citations1. Masson, D. et al. (2009) Int J Mol Med. 23: 41 2. Chodynicka, B. et al. (2008) J European Acad Dermatol & Venereol. 22: 712 3. Coffey, RJ. et al. (2008) Clin Cancer Res. 14: 1182 4. Blobel, CP. et al. (2007) J Immunol. 179: 2689 Technical Protocols |
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