Anti-Human TACE (CT)

Pricing & Details

Product No.T203
Protein
TACE
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Tumor Necrosis Factor-α Converting Enzyme, ADAM17, CD156b, MGC71942, cSVP
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T203-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
T203-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:T204
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TNF-α Converting Enzyme (TACE) recognizes an epitope near the C-terminus of Human, Mouse and Rat TACE. This polyclonal antibody was purified using affinity chromatography.
Background
TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.1 TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.2 TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)3 and a principal target for the treatment of TNF-dependent pathologies.4

Antigen Details

Protein
PubMed

References & Citations

1. Masson, D. et al. (2009) Int J Mol Med. 23: 41
2. Chodynicka, B. et al. (2008) J European Acad Dermatol & Venereol. 22: 712
3. Coffey, RJ. et al. (2008) Clin Cancer Res. 14: 1182
4. Blobel, CP. et al. (2007) J Immunol. 179: 2689
IHC
General Western Blot Protocol
Prod No.
Description
T203
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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