Anti-Human Transmembrane Activator & CAML Interactor (TACI)

Anti-Human Transmembrane Activator & CAML Interactor (TACI)

Product No.: T221

[product_table name="All Top" skus="T221"]

- -
- -
Target
TACI
Product Type
Polyclonal Antibody
Alternate Names
Transmembrane Activator & Calcium Modulator and Cyclophilin Ligand, TNFRSF13B, CD267, CVID, FLJ39942, MGC133214, MGC39952, TNFRSF14B
Applications
B
,
IHC FF
,
WB

- -
- -
Product Size
- -
- -

Antibody Details

Product Details

Reactive Species
Human
Host Species
Goat
Immunogen
Purified Recombinant Human TACI (>98%)
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Formulation
This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
State of Matter
Lyophilized
Storage and Handling
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Applications and Recommended Usage?
Quality Tested by Leinco
Western Blot: Suitable for use at concentration of 0.1 µg/mL.
Additional Applications Reported In Literature ?
Immunohistochemistry: Suitable for use at concentration of 5-15 µg/mL.
Blocking: In a functional ELISA, 0.075-0.3 µg/mL of this antibody will block 50% of the binding of 50 ng/mL of Recombinant Human BAFF/BLyS/TNFSF13B o immobilized Recombinant Human TACI/TNFRSF13B Fc Chimera coated at 1 µg/mL (100 µL/well). At 10 μg/mL, this antibody will block >90% of the binding.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Goat Anti-Human Transmembrane Activator & CAML Interactor (TACI) recognizes Human TACI. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Background
Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member1,2 of the tumor necrosis factor-receptor superfamily3 and is expressed in B-lymphocytes and may act to regulate humoral immunity.4 TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL).5

Antigen Details

PubMed
NCBI Gene Bank ID

References & Citations

1. Schwaller, J. et al. (2007) Blood 109:331
2. Slazer, U. et al. (2005) Nat Genet. 37:820
3. Bonilla, FA. et al. (2006) Curr Allergy Asthma Rep. 6:357
4. Bram, RJ. et al. (2000) Mamm Genome. 11:628
5. Kobata, T. et al. (2007) Blood 109: 2961
B
IHC FF
General Western Blot Protocol
- -
- -
Products are for research use only. Not for use in diagnostic or therapeutic procedures.