Anti-Human Target of Rapamycin (TOR)

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Target of Rapamycin (TOR) recognizes Human and Mouse TOR. This polyclonal antibody was purified using affinity chromatography.

The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1). It was initially discovered as a kinase whose ability to stimulate T cell proliferation in response to IL-2 could be inhibited by the immunosuppressive drug rapamycin.^2,3 Rapamycin inhibits TOR in other cell types resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 4). TOR is normally associated with the regulatory proteins RAPTOR and GβL. Its downstream targets are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs). Regulation of these protein families allows TOR to control protein biosynthesis.⁴

1. Shamji, AF. et al. (2003) Mol. Cell 12:271
2. Sabatini, DM. et al. (1994) Cell 78:35
3. Cardenas, ME. et al. (1995) Curr. Opin. Nephrol. Hypertens. 4:472
4. Fingar, DC. et al.(2004) Oncogene 23:3151