Anti-Human TSH-β [Clone 195] — Purified
Anti-Human TSH-β [Clone 195] — Purified
Product No.: T102
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Clone 195 Target Thyroid Stimulating Hormone Beta Formats AvailableView All Product Type Monoclonal Antibody Alternate Names HCG, GPH, GPHA1, CGA, Thyrotropin Isotype IgG |
Data
TSH LOD GraphThe graph demonstrates a strong, wide-ranging dose-response for human TSH. This was achieved using the T114 gold conjugate antibody and the T102 nitrocellulose membrane antibody. The data from recombinant TSH samples suggests an estimated Limit of Detection (LoD) of 125 μlU/mL or less.
TSH LFA ImageThis TSH Lateral Flow Assay image demonstrates that a clear signal on the test line begins at 500 μlU/mL of rhTSH and gets stronger as the concentration increases to 2000 μlU/mL. The control line stays consistently positive at all concentrations. The antibody pair used was Leinco detection antibody T114 and capture antibody T102.
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified Recombinant Human TSH-β (>98%) Product Concentration ≥ 5.0 mg/ml Purity ≥95% by SDS Page Formulation This purified antibody is supplied in 0.05 M phosphate buffered saline (PBS), pH 7.2 - 7.4, containing 0.1% sodium azide. as a preservative. State of Matter Liquid Storage and Handling This Purified Antibody is stable when stored at 2-8°C. Do not freeze. Cross Reactivity Paired with Leinco Prod. No. T100, Clone No. 154: TSH 100%, BhCG < 1%, ihCG < 1%, LH <1%, FSH < 1%.
Paired with Leinco Prod. No. T101, Clone No. 183: TSH 100%, BhCG < 1%, ihCG < 1%, LH 1%, FSH < 1%.
Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2737562 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Anti-Human Thyroid Stimulating Hormone Beta (TSH-β) (Clone 195) recognizes Human Thyroid Stimulating Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Thyroid-stimulating hormone (TSH), also known as thyrotropin, is a glycoprotein hormone1 that regulates the endocrine function of the thyroid gland.2 The most important controller of TSH secretion is thyroid-releasing hormone. Thyroid-releasing hormone is secreted by hypothalamic neurons into hypothalamic-hypophyseal portal blood, finds its receptors on thyrotrophs in the anterior pituitary and stimulates secretion of TSH.1 Independent of age, thyroid cancer incidence correlates with higher TSH. Higher TSH is associated with extrathyroidal extension of disease.3 Research Area Hormones . IVD Raw Material References & Citations1. (1998) Bowen A
2. McPherson et al. (2000) Placenta 24: 941
3. Wenger, R H et al. (2003) Wildmann's Clinical Interpretation of Laboratory Tests
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
