Anti-Human TIRP (CT-1)

Pricing & Details

Product No.T361
Protein
TIRP
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
TRAM, TICAM2
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T361-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
T361-0.1 mg
0.1 mg
$395.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:T366
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TIRP recognizes an epitope near the C-terminus of Human TIRP. This polyclonal antibody was purified using affinity chromatography.
Background
TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-?B (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

Antigen Details

Protein
PubMed

References & Citations

1. Bowie, AG. et al. (2003) Trends in Imm. 24:286-9.
2. Fenton, MJ. et al. (2003) Mol. Interv. 3:466-77.
3. Akira, S. et al. (2003) Annu.Rev. Immunol. 21:335-76.
4. Janeway Jr., CA. and Medzhitov, R. (2002) Annu. Rev. Immunol. 20:197-216.
5. Shu, HB. et al. (2003) J. Biol. Chem.278:24526-24532.
6. Barnes, BJ. et al. (2003) J. Exp. Med. 198:1043-1055.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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