Anti-Human TNF Receptor-Associated Factor 3 (CT-2) (TRAF3)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human TNF Receptor-Associated Factor 3 (CT-2) (TRAF3)

Pricing & Details

Product No.T285
Protein
TNF Receptor-Associated Factor 3
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
CD40 Binding Protein, LMP1 Associated Protein 1, CD40BP, LAP1
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T285-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
T285-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TNF Receptor-Associated Factor 3 (TRAF3) recognizes an epitope near the C-terminus of Human, Mouse and Rat TRAF3. This polyclonal antibody was purified using affinity chromatography.
Background
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily.1 TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1.2,3 Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-κB.4 Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-β receptor (LTβR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTβR.

Antigen Details

References & Citations

1. Arch, RH. et al. (1998) Genes Dev. 12:2821
2. Cheng, G. et al. (1995) Science 267:1494
3. Mosialos, G. et al. (1995) Cell 80:389
4. van Eyndhoven, WG. et al. (1999) Mol. Immunol. 36:647
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Leinco Technologies uses cookies to improve your experience and our website service. By continuing to browse our website, you accept our cookie policy. Ok