This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human TNF Receptor-Associated Factor 6 (TRAF6) recognizes an epitope near the C-terminus of Human, Mouse and Rat TRAF6. This polyclonal antibody was purified using affinity chromatography.
Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-κB.1,2 TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families.3 TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands.4 It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.
References & Citations
1. Takeda, K. et al. (2003) Annu. Rev. Immunol. 21:335
2. Wu, H. (2004) Adv. Protein Chem. 68:225
3. Wajant, H. et al. (2004) Prog. Mol. Subcell. Biol. 34:47
4. Kobayashi, T. et al. (2003) Immunity 19:353
Products are for research use only. Not for use in diagnostic or therapeutic procedures.