Anti-Human TRAIL R4 (Internal Domain)

Anti-Human TRAIL R4 (Internal Domain)

Product No.: D248

[product_table name="All Top" skus="D248"]

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Target
TNF-Related Apoptosis-Inducing Ligand Receptor 4
Product Type
Polyclonal Antibody
Alternate Names
TNFRSF10D, Decoy Receptor 2 (DCR2), CD264, TRUNDD, TR4
Applications
IHC FFPE
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:D266
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TNF-Related Apoptosis-Inducing Ligand Receptor 4 (TRAIL R4) recognizes Human TRAIL R4. This polyclonal antibody was purified using affinity chromatography.
Background
TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1,2

Antigen Details

References & Citations

1. Chan, FK. et al. (2005) Proc Natl Acad Sci USA 102: 18099
2. Sanlioglu, S. et al. (2005) BMC Cancer 5: 54
IHC FFPE
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.