Anti-Human TRIM5γ

Pricing & Details

Product No.T334
Protein
TRIM5γ
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T334-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
T334-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TRIM5γ recognizes Human TRIM5γ. This polyclonal antibody was purified using affinity chromatography.
Background
TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region.1 TRIM5 has five alternately spliced isoforms, the longest of which is the variant which also contains a carboxy-terminal B30.2 (SPRY) domain.1 While a function has not yet been assigned to TRIM5γ, it is known that expression of TRIM5γ variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1,2,3 albeit at differing efficiencies. Furthermore, the TRIM5γ isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.4

Antigen Details

Protein
PubMed

References & Citations

1. Reymond, A. et al. (2001) EMBO J. 20:2140 2. Stremlau, M. et al. (2004) Nature 427:848 3. Hatziioannou, T. et al. (2004) Proc. Nat’l. Acad. Sci. USA 101:10774 4. Xu, L. et al. (2003) Exp. Cell Res. 288:84
IHC
General Western Blot Protocol
Prod No.
Description
T334
T340
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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