This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human Tyrosine Kinase Substrate p62dok (p62 DOK) recognizes an epitope near the C-terminus of Human p62 DOK. This polyclonal antibody was purified using affinity chromatography.
Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.
References & Citations
1. Carpino, N. et al. (1997) Cell 88:197
2. Yamanashi, Y. et al. (1997) Cell 88:205
3. Holland, SJ. et al. (1997) EMBO J. 16:3877
4. Di Cristofano, A. et al. (1998) J. Biol. Chem. 273:4827
Products are for research use only. Not for use in diagnostic or therapeutic procedures.