Anti-IP6K2 Antibody (11018)
Anti-IP6K2 Antibody (11018)
Product No.: 11018
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Clone 4F10 Target IP6K2 Formats AvailableView All Product Type Monoclonal Alternate Names InsP6 kinase 2, InsP6K2, EC 2.7.4.-, P(i-uptake stimulator, PiUS Isotype Mouse IgG2b Applications WB |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Full-length recombinant human IP6K2. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: A band of ~49 kDa is detected. User should determine optimal concentrations for their application.
Positive control: purified human IP6K2 or NIH-OVCAR-3 cells after treatment with interferon (IFN)-b. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to IP6K2 Background Inositol hexakisphosphate kinase 2 (IP6K2) catalyzes the production of diphosphoinositol pentakisphosphate (IP7) and has a role as a proapoptotic gene sensitizing cancer cells to apoptosis by cell stressors and anticancer drugs all of which depend on IP6K2 catalytic activity. IP6K2 is located in the 3p21.31 chromosomal region, which often undergoes allele loss in a variety of human cancers. Some heat shock proteins, especially Hsp90, can be antiapoptotic and the targets of anticancer drugs. Hsp90 binds IP6K2 and inhibits its catalytic activity. Drugs and selective mutations that abolish HSP90-IP6K2 binding elicit activation of IP6K2, leading to cell death. Thus, the prosurvival actions of HSP90 reflect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effective and safer modes of chemotherapy. Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {PubMed:10574768, PubMed:30624931}. NCBI Gene Bank ID UniProt.org Research Area Apoptosis References & CitationsMorrison, BH et al. 2002 Oncogene 21: 1882-1889. Technical Protocols Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
