Anti-Mouse CD80 – DyLight® 650

Anti-Mouse CD80 – DyLight® 650

Product No.: C2246

[product_table name="All Top" skus="C2246"]

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Clone
16-10A1
Target
B7-1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
B7-1, B71, Ly53, TSA1, Cd28l, Ly-53, MIC17
Isotype
IgG
Applications
FC
,
ICC

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Armenian Hamster
Immunogen
Purified Recombinant Mouse cd80 (>98%)
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Red Laser (652 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 16-10A1 recognizes an epitope on mouse CD80.
Background
CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B7-2) to prime T- cells. CD80 binds to CTLA-4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cell-mediated cell death of the CD80 carrier. The activation of Natural Killer cell-mediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.
Antigen Distribution
CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells.

Antigen Details

Ligand/Receptor
CD28 (stimulatory), CD152(CTLA4) (inhibitory)
PubMed
NCBI Gene Bank ID
Research Area
Cell Biology
.
Costimulatory Molecules
.
Immunology
.
Neuroscience
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Neuroscience Cell Markers
Flow Cytometry
ICC

Certificate of Analysis

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Formats Available

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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.