Anti-Mouse Caspase Activated Deoxyribonuclease (CT) (CAD)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Mouse Caspase Activated Deoxyribonuclease (CT) (CAD)

Pricing & Details

Product No.C1109
Protein
Caspase Activated Deoxyribonuclease
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
DFF40
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1109-20 µg
20 µg
$115.00
In stock
Max:
Min: 1
Step: 1
C1109-0.1 mg
0.1 mg
$425.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Rabbit
Immunogen
PN:C1125
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Mouse Caspase Activated Deoxyribonuclease (CAD) recognizes an epitope near the C-terminus of Mouse CAD. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease).1,2 The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40.3,4 Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively.1,2,5 Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei.1-4 Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

Antigen Details

References & Citations

1. Enari, M. et al. (1998) Nature 391:43-50
2. Sakahira, H. et al. (1998) Nature391:96-99
3. Liu, X. et al. (1998) Proc Natl Acad Sci USA 95:8461-6
4. Halenbeck, R. et al. (1998) Curr Biol 8:537-40
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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