Anti-Mouse CD122 (IL-2Rβ) – Biotin

Anti-Mouse CD122 (IL-2Rβ) – Biotin

Product No.: C2327

[product_table name="All Top" skus="C2327"]

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Clone
TM-β1
Target
CD122
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Interleukin 2 receptor β chain, IL-2/15Rb
Isotype
IgG2b

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rat
Immunogen
Rat T-cell line expressing Mouse IL-2Rβ
Product Concentration
0.5 mg/ml
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
FC The suggested concentration for this TM-β1 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone TM-β1 recognizes an epitope on mouse CD122.
Antigen Distribution
CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages.
Background
CD122 is a 70-75 kD IL-2 receptor β chain that is a type I membrane protein. CD122 is involved in T cell-mediated immune responses and its activation increases proliferation of CD8+ effector T cells. It exists in three forms with varying degrees of binding affinity with IL-2. The low affinity form is a monomer of the α subunit and has no involvement in signal transduction. The intermediate affinity form is a γ/β heterodimer and the high affinity form is an α/β/γ heterotrimer. The intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. This protein also interacts with the IL-15 receptor.

Antigen Details

Ligand/Receptor
IL-2, IL-15
PubMed
NCBI Gene Bank ID
Research Area
Immunology

References & Citations

1. Burchill, MA. et al. (2007) J. Immunol. 178:280
2. Friedmann, MC. et al. (1996) Proc. Natl. Acad. Sci. (USA) 93:2077
3. Leonard, WJ. et al. (1987) Science 238:75

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.