Anti-Mouse CD200 (Clone OX-90) – Purified in vivo PLATINUM™ Functional Grade

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.

Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUM^TM antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Next Day 2-8°C

Clone OX-90 reacts with murine CD200 (OX-2).

CD200 (OX-2) is an immune suppressor that regulates the of induction of cytokine production by conventional allostimulatory DC^1,2. CD200 limits pro-inflammatory signals and has been shown to play an important role in cancer and immune disorders^3,4.

Thymocytes, neurons, B cells, splenic follicular dendritic cells and endothelium, and subsets of T cells and dendritic cells

1. Gorczynski L, Chen Z, Hu J, et. al. J Immunol. Jan 15;162(2):774-81. 1999.
2. Koning N, Swaab DF, Hoek RM, Huitinga I. J Neuropathol Exp Neurol. Feb;68(2):159-67. 2009.
3. Stanley H. Appel, David R. Beers, Weihua Zhao. Neurobiology of Brain Disorders.
4. Liu JQ, Hu A, Zhu J, et. al. Adv Exp Med Biol. 1223:155-165. 2020.