≥ 5.0 mg/ml
<0.5 EU/mg as determined by the LAL method
≥98% monomer by analytical SEC
>95% by SDS Page
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Functional grade preclinical antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUMTM antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Storage and Handling
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day 2-8°C
Other Applications Reported In Literature ?
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Clone OX-90 reacts with murine CD200 (OX-2).
Thymocytes, neurons, B cells, splenic follicular dendritic cells and endothelium, and subsets of T cells and dendritic cells
CD200 (OX-2) is an immune suppressor that regulates the of induction of cytokine production by conventional allostimulatory DC1,2. CD200 limits pro-inflammatory signals and has been shown to play an important role in cancer and immune disorders3,4.
References & Citations
1. Gorczynski L, Chen Z, Hu J, et. al. J Immunol. Jan 15;162(2):774-81. 1999.
2. Koning N, Swaab DF, Hoek RM, Huitinga I. J Neuropathol Exp Neurol. Feb;68(2):159-67. 2009.
3. Stanley H. Appel, David R. Beers, Weihua Zhao. Neurobiology of Brain Disorders.
4. Liu JQ, Hu A, Zhu J, et. al. Adv Exp Med Biol. 1223:155-165. 2020.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.