Anti-Mouse CD278 (ICOS) – Biotin

Anti-Mouse CD278 (ICOS) – Biotin

Product No.: C2259

[product_table name="All Top" skus="C2259"]

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Clone
7E.17G9
Target
CD278
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Inducible Costimulator, ICOS
Isotype
IgG2b
Applications
FC

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Immunogen
Purified Recombinant Mouse ICOS
Product Concentration
0.5 mg/ml
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 7E.17G9 recognizes an epitope on mouse CD278.
Background
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
Antigen Distribution
ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.

Antigen Details

Ligand/Receptor
B7h/B7RP-1/GL-50
PubMed
NCBI Gene Bank ID
Research Area
Costimulatory Molecules
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Immunology

References & Citations

1. Flavell, R. A. et al. (2001) Nature 409:97 2. Bachmann, M. F. et al. (2000) J. Exp. Med. 192:53 3. Kroczek, R. A. et al. (1999) Nature 397:263
Flow Cytometry

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.