Antibody DetailsProduct DetailsReactivity Species Mouse Host Species Rat Immunogen BALB/c mouse B lymphoma A20.J2 Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829498 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this FR70 antibody for staining cells in flow cytometry is ≤ .25 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? IP B IHC (Frozen) For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone FR70 recognizes an epitope on mouse CD70. Antigen Distribution CD70 is expressed by highly activated lymphocytes as found in T-cell and B-cell lymphomas. Background CD70 is a 30-33 kD type II transmembrane glycoprotein and a member of the TNF superfamily. CD70 is the ligand for CD27; the binding of which delivers costimulatory signals to T cells and NK cells. CD70 is expressed on highly activated lymphocytes characteristic of T- and B-cell lymphomas. Because normal lymphocytes have low CD70 expression, it has been suggested that anti-CD70 antibodies may be a possible treatment for CD70 positive lymphomas. CD70-specific antibodies are currently under investigation for the treatment of hematological malignancies and renal cell carcinoma. Antigen DetailsProtein Ligand/Receptor CD27 PubMed NCBI Gene Bank ID UniProt.org Research Area Costimulatory Molecules . Immunology Technical Protocols |
Formats Available
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C2402 |
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C2404 |
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C2405 |
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C2406 |
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