Anti-Mouse IL-1 R1, Type 1 – PE

Pricing & Details

Product No.I-433
Clone
JAMA-147
Protein
Interleukin-1 R1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD121a, Interleukin-1 R1
Isotype
Armenian Hamster
IgG
Applications
FC
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-433-50 µg
50 µg
$110.00
In stock
Max:
Min: 1
Step: 1
I-433-500 µg
500 µg
$302.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Armenian Hamster
Immunogen
Extracellular domain of mouse IL-1R1
Product Concentration
0.2 mg/ml
Formulation
This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation
This monoclonal antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Storage and Handling
This R-PE conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Blue Laser (488 nm) and/or Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Applications and Recommended Usage?
Quality Tested by Leinco
Flow Cytometry The suggested use of this antibody is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution
T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells, neural cells
Background
IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1α and IL-1ß exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1ß, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.

Antigen Details

Function
Innate and adaptive immune response
Research Area
Immunology
.
Innate Immunity
Flow Cytometry

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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