Anti-Mouse IL-1 R1, Type 1 – Purified

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Pricing & Details

Product No.I-432
Clone
JAMA-147
Protein
Interleukin-1 R1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Interleukin-1 R1
Isotype
Armenian Hamster
IgG
Applications
FC
,
IP
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-432-50 µg
50 µg
$77.00
In stock
Max:
Min: 1
Step: 1
I-432-500 µg
500 µg
$225.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Armenian Hamster
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
IL-1 was one of the first cytokines to be described. The IL-1 family consists of three members including IL-1α, IL-1ß and IL-1 receptor antagonist (IL-1Ra). IL-1α and IL-1ß produce similar or identical biological responses and IL-1Ra is an endogenous inhibitor that blocks and buffers IL-1α and IL-1ß actions. Each family member is expressed by a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1α is retained inside of the cell or is expressed on the cell surface and acts as an autocrine messenger, while IL-1ß is secreted. IL-1α and IL-1ß elicit a broad range of actions including induction of fever, hypotension, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Binding of IL-1α by ALF-161 neutralizes the biological effects of IL-1α.

Antigen Details

Research Area
Immunology
.
Innate Immunity
Flow Cytometry
Immunoprecipitation Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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