Anti-Mouse IL-1 R1, Type 1 – Purified

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This purified antibody is stable when stored at 2-8°C. Do not freeze.

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Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

IL-1 was one of the first cytokines to be described. The IL-1 family consists of three members including IL-1α, IL-1ß and IL-1 receptor antagonist (IL-1Ra). IL-1α and IL-1ß produce similar or identical biological responses and IL-1Ra is an endogenous inhibitor that blocks and buffers IL-1α and IL-1ß actions. Each family member is expressed by a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1α is retained inside of the cell or is expressed on the cell surface and acts as an autocrine messenger, while IL-1ß is secreted. IL-1α and IL-1ß elicit a broad range of actions including induction of fever, hypotension, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Binding of IL-1α by ALF-161 neutralizes the biological effects of IL-1α.