Anti-Mouse IL-4 (Clone 11B11) – DyLight® 650

Home/Primary Monoclonal Antibodies/Surfacetag Mouse CD Markers/Anti-Mouse IL-4 (Clone 11B11) – DyLight® 650

Pricing & Details

Product No.I-1080
Clone
11B11
Protein
IL-4
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Interleukin-4, BCGF, BCDF, B Cell Stimulating Factor, BSF-1, IaIF, HCGF, MCGF2, MFF, TCGF-2
Isotype
Rat
IgG1 κ
Applications
ICFC
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-1080-50 µg
50 µg
$135.00
In stock
Max:
Min: 1
Step: 1
I-1080-100 µg
100 µg
$215.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Rat
Immunogen
Partially Purified Native Mouse IL-4
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation
The antibody was purified by affinity chromatography and conjugated with DyLight 650 under optimal conditions.
Storage and Handling
This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Red Laser (652 nm)
Other Applications Reported In Literature ?
ICFC
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 11B11 recognizes an epitope on mouse IL-4.
Antigen Distribution
IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils.
Background
IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1,2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3,4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6,7 and airway inflammation in patients with asthma8.

Antigen Details

Protein
PubMed
NCBI Gene Bank ID
Research Area
Immunology

References & Citations

1. Yoshimoto T & Paul WE. (1994) J Exp Med. 179(4):1285–95
2. Kipnis J., at al. (2012) J Immunol. 189(9):4213-4219
3. Groth B., et al. (1992) J Exp Med. 176:1091–8
4. Murphy KM., et al. (1992) Proc Natl Acad Sci USA. 89:6065–9
5. Paul WE., et al. (1999) Annual Rev Immunol. 17:701-38
6. Maquart FX., et al. (2000) Lab Invest. 80(8):1337-43
7. Godeau, G., et al. (2000) Lab Invest. 80,1337–1343
8. Steinke JW & Borish L. (2001) Respir Res. 2(2):66-70

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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