Anti-Mouse MAdCAM-1 (MECA-367) – DyLight® 488

Mouse Endothelial Cells

This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This DyLight^® 488 conjugate is stable when stored at 2-8°C. Do not freeze.

Research Use Only

2 - 8°C Wet Ice

Blue Laser (493 nm)

Rat Anti-Mouse MAdCAM-1 (Clone MECA-367) recognizes an epitope on Mouse MAdCAM-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking.¹ MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract.² MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity.³

Integrin a4ß7, CD62L

1. Briskin MJ et al. (1995) J Immunol. 155: 2477 2. Jackson D et al. (1997) Immunol Res. 16: 299 3. Ringler DJ et al. (1997) Am J Pathol. 151: 97